San Francisco Chapter of the American Statistical Association Seminar

Speaker:	Gregory E Alexander, Director of Biostatistics, Genomic Health, Inc.
Time:	May 12th, 2015 4:30-6:00pm (4:30-5:00 networking/refreshment; 5:00-6:00 seminar)
Location:	Genomic Health campus, Buzz Conference room 101 Galveston Drive, Redwood City, CA
Title:	Comparisons of statistical modeling, simulation, and experimental data from genomic assays

Abstract:

An assessment of the impact of interfering substances on an assay is often needed as part of the validation process. In the case of a polymerase chain reaction (PCR) based assay used to quantitate RNA expression, we model the effects of genomic DNA on individual assays and on composite scores formed by aggregating over a collection of gene assays. Modeling and simulations suggest a somewhat non-intuitive result, which is largely confirmed by actual experimental data. In a second example we explore ways to aggregate large number DNA markers derived through next generation sequencing (NGS) and compare results applied to simulated data to results from actual sequencing experiments. An overview of PCR and NGS analytical methods will be provided, however attendees may benefit from prior review of these methodologies.

Please note pre-registration is highly recommended to expedite check-in process. Please send participant's name and affiliation to sfasaofficers@gmail.com by the end of May 10^th, Thanks!

Direction for the location:

Direction to the conference room:

The conference room is located in the building at 101 Galveston Drive from main entrance. Upon arrival please check in at Reception and receive a visitor’s badge. Reception staff will assist with directing to Buzz conference room and there will be directional signs along the walking path. Pre-registration with SFASA will be highly recommended to expedite the check-in process.

Directions to Genomic Health Corporate Headquarters at 101 Galveston Drive, Redwood City, CA:

From I-280

Exit Woodside Road East
After approx. 4 miles Woodside Road will turn into Seaport Blvd when you go under the Hwy 101 overpass
Turn Left onto Chesapeake Drive (2nd traffic signal after Hwy 101 overpass)
Make an immediate Left onto Galveston Drive
Make an immediate left into the first driveway, 101 Galveston is the first building on the left as you enter the parking lot.

From San Francisco Airport via Hwy 101 South

Exit Woodside/Seaport Blvd/CA-84 and proceed LEFT towards Seaport Blvd
Merge onto Seaport Blvd
Turn Left onto Chesapeake Drive (2nd traffic signal)
Make an immediate Left onto Galveston Drive
Make an immediate left into the first driveway, 101 Galveston is the first building on the left as you enter the parking lot.

From San Jose Airport via Hwy 101 North

Exit Woodside/Seaport Blvd/CA-84 proceed RIGHT towards Seaport Blvd
Merge onto Seaport Blvd
Turn Left onto Chesapeake Drive (2nd traffic signal)
Make an immediate Left onto Galveston Drive Make an immediate left into the first driveway, 101 Galveston is the first building on the left as you enter the parking lot.